01 / Reference identity
Identity at a glance.
Public records describe PE-22-28 as one seven-residue peptide, GVSWGLR, ending in a free acid. The same seven residues end the longer spadin chain. The values below are for the free peptide; the salt form of a supplied lot follows its own record.
| Sequence, three-letter | Gly–Val–Ser–Trp–Gly–Leu–Arg |
|---|---|
| Sequence, one-letter | GVSWGLR |
| Length | 7 residues |
| C-terminus | Free acid |
| Formula, free peptide | C35H55N11O9 |
| Molecular weight, free peptide | 773.9 g/mol |
| CAS number | 1801959-12-5 |
| PubChem CID | 165437303 |
02 / Molecular architecture
A closer look at the chain.
Its reference chain is Gly–Val–Ser–Trp–Gly–Leu–Arg. The reference record shows a C-terminal acid rather than an amidated ending.
- 7 amino acids
- Spadin-related fragment
- TREK-1 research
- 1Gly
- 2Val
- 3Ser
- 4Trp
- 5Gly
- 6Leu
- 7Arg
Reference information: [1][2][3]. Actual lot identity must be verified separately.
A seven-residue fragment identity.
The GVSWGLR sequence is the compact reference shown for PE-22-28. A fragment designation relates the molecule to a larger reference, but the fragment is its own specified material. The C-terminal acid and residue order distinguish the described chain beyond the spadin-related naming history.
Reading an ion-channel experiment.
TREK-1 is the ion-channel context in the cited reference. Electrophysiological measurements report electrical behavior under defined experimental conditions. They are a different type of evidence from a receptor-binding result or a mass spectrum, so the expression system and measured electrical endpoint belong alongside any comparison.
Structure and research references: [1]
03 / Read the evidence
Research & analytical context.
The reference describes electrophysiological measurements in cells expressing TREK-1. This is an ion-channel assay context. The named fragment, terminal chemistry and expression system are necessary details when comparing experimental records.
Read the references: [1][2][3].
The distinction that matters
PE-22-28 and full-length spadin are different reference materials. Confirm the fragment and terminal chemistry rather than treating a shared research target as proof of identical structure.
04 / From reference to record
Know the lot, too.
A publication describes its own test material. Your lot’s certificate describes what was tested on that lot. Keep the compound name, batch number and reported methods together when reviewing a result.
Identity & composition
Check sequence or chemical form, terminal modifications, counterion and—where relevant—each blend component.
Analytical results
Read purity, content, sterility and endotoxin results as separate measurements. Only call a test passed when the actual report supports it.
Handling & storage notes
Lyophilized material: Store at −20°C; protect from light and moisture.
Follow the material-specific label and supporting storage documentation. These temperatures do not establish a shelf life.
How to store lyophilized peptides05 / Reference questions
A few details, explained.
Does PE-22-28 contain twenty-eight residues?
No. The reference shown is a seven-residue fragment. Numbers in a fragment designation should not be assumed to state the total length of the final peptide.
What does the OH at the end mean?
It denotes the C-terminal acid in the reference notation. It is not another residue and is chemically distinct from an amidated ending written NH₂.
Read alongside the references: [1]
06 / Continue reading
Go to the source.
Each source is labeled by its type. External sources are not Pioneer batch certificates.
- Cayman Chemical · PE-22-28 structure and original study referencesSupplier reference · Read source (opens a new tab)
- PubChem · PE-22-28 identity record, CID 165437303Public record · Read source (opens a new tab)
- Cayman Chemical · Spadin sequence referenceSupplier reference · Read source (opens a new tab)