01 / Reference identity
Identity at a glance.
Public records describe MOTS-C as one 16-residue peptide whose sequence is encoded in the mitochondrial 12S rRNA gene, MT-RNR1. The values below are for the free peptide; the salt form of a supplied lot follows its own record.
| Sequence, three-letter | Met–Arg–Trp–Gln–Glu–Met–Gly–Tyr–Ile–Phe–Tyr–Pro–Arg–Lys–Leu–Arg |
|---|---|
| Sequence, one-letter | MRWQEMGYIFYPRKLR |
| Length | 16 residues |
| Encoded by | Mitochondrial 12S rRNA gene (MT-RNR1) |
| Formula, free peptide | C101H152N28O22S2 |
| Molecular weight, free peptide | 2174.6 g/mol |
| CAS number | 1627580-64-6 |
| PubChem CID | 146675088 |
| UniProt | A0A0C5B5G6 |
02 / Molecular architecture
A closer look at the chain.
MOTS-C is one chain of 16 residues, MRWQEMGYIFYPRKLR, encoded in the mitochondrial 12S rRNA gene. It holds two methionines (positions 1 and 6), two tyrosines (8 and 11) and three arginines (2, 13 and 16), and no cysteine. It is a small peptide, not one of the large protein complexes inside mitochondria.
- 16 residues
- Mitochondrial-derived peptide
- 12S rRNA-associated ORF
- 1Met
- 2Arg
- 3Trp
- 4Gln
- 5Glu
- 6Met
- 7Gly
- 8Tyr
- 9Ile
- 10Phe
- 11Tyr
- 12Pro
- 13Arg
- 14Lys
- 15Leu
- 16Arg
Reference information: [1][2][3][4]. Actual lot identity must be verified separately.
A peptide associated with a mitochondrial sequence.
An open reading frame, or ORF, is a nucleotide region that can encode a peptide sequence. The MOTS-C discovery reference places its short ORF within the mitochondrial 12S rRNA region. This describes its genetic reference; the sixteen-residue peptide is not an RNA molecule or a mitochondrial organelle.
Localization and expression are different readouts.
The cell-based work examined stress-dependent nuclear localization and changes associated with gene expression. Detecting a peptide in a cellular compartment and measuring an expression response are distinct observations. Understanding the experimental stress and readout helps separate a localization finding from a broader interpretation of cellular signaling.
03 / Read the evidence
Research & analytical context.
Cell-based research examined stress-dependent nuclear localization and gene expression associated with MOTS-C. These measurements address where the peptide was detected and the responses of the tested cell system; they are separate from batch identity and purity measurements.
Read the references: [1][2][3][4].
The distinction that matters
A mitochondrial genetic origin describes where the sequence is encoded, not a property of a supplied material. Findings from cell-based work must be read in the context of their specific stress conditions and experimental model.
04 / From reference to record
Know the lot, too.
A publication describes its own test material. Your lot’s certificate describes what was tested on that lot. Keep the compound name, batch number and reported methods together when reviewing a result.
Identity & composition
Check sequence or chemical form, terminal modifications, counterion and—where relevant—each blend component.
Analytical results
Read purity, content, sterility and endotoxin results as separate measurements. Only call a test passed when the actual report supports it.
Handling & storage notes
Lyophilized material: Store at −20°C; protect from light and moisture.
Follow the material-specific label and supporting storage documentation. These temperatures do not establish a shelf life.
How to store lyophilized peptides05 / Reference questions
A few details, explained.
Does mitochondrial-derived mean it is a mitochondrion?
No. It describes the peptide’s relationship to a mitochondrial genetic reference. MOTS-C is a short peptide, separate from the organelle and the large molecular complexes within it.
Is MOTS-C the same type of molecule as NAD+?
No. MOTS-C is a peptide chain. NAD+ is a nucleotide-based cofactor. Their appearance in cellular research does not make their chemistry or experimental roles interchangeable.
06 / Continue reading
Go to the source.
Each source is labeled by its type. External sources are not Pioneer batch certificates.
- Lee et al. · MOTS-C discovery (2015)Published research · Read source (opens a new tab)
- MOTS-C and stress-dependent nuclear signaling (2018)Published research · Read source (opens a new tab)
- PubChem · MOTS-C identity record, CID 146675088Public record · Read source (opens a new tab)
- UniProt · MOTS-c sequence record, A0A0C5B5G6Public record · Read source (opens a new tab)