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For laboratory research use only · Not for human consumption
Pioneer Labs

Fragments / Research guide

AOD-9604.

A little deeper. A clearer picture.

A fragment-based design with a compact disulfide loop. AOD-9604 is a synthetic peptide related to the C-terminal region of growth hormone, rather than the complete hormone.

For research use onlyView AOD-9604 sizes
Published by Pioneer LabsUpdated Sources & editorial standards

01 / Reference identity

Identity at a glance.

Public records describe AOD-9604 as one 16-residue peptide whose two cysteines, at positions 7 and 14, are joined by a disulfide bond. The formula and weight below are for the bridged free peptide; the salt form of a supplied lot follows its own record.

AOD-9604 reference identity
Sequence, three-letterTyr–Leu–Arg–Ile–Val–Gln–Cys–Arg–Ser–Val–Glu–Gly–Ser–Cys–Gly–Phe
Sequence, one-letterYLRIVQCRSVEGSCGF
Length16 residues
Disulfide bondCys7–Cys14
Formula, bridged free peptideC78H123N23O23S2
Molecular weight, bridged free peptide1815.1 g/mol
CAS number221231-10-3
PubChem CID71300630
Reference values from public records, not a Pioneer lot specification.

References: [1][2]

02 / Molecular architecture

A closer look at the chain.

AOD-9604 is one chain of 16 residues, YLRIVQCRSVEGSCGF, beginning with tyrosine. Its two cysteines, at positions 7 and 14, are joined by a disulfide bond. That connection constrains part of the chain; a straight sequence alone does not show its complete geometry.

Pioneer / Reference notesMolecular features
  • 16 amino acids
  • Tyrosine at the N-terminus
  • Cys7–Cys14 bridge
  1. Tyr
  2. Leu
  3. Arg
  4. Ile
  5. Val
  6. Gln
  7. Cys
  8. Arg
  9. Ser
  10. Val
  11. Glu
  12. Gly
  13. Ser
  14. Cys
  15. Gly
  16. Phe
YLRIVQCRSVEGSCGF reference sequence, read from the N-terminus; Cys7 and Cys14 are joined by a disulfide bond. Salt form must be checked separately.

Reference information: [1][2]. Actual lot identity must be verified separately.

One chain, with a connection across it.

A peptide backbone links residues in order. AOD-9604 adds a second kind of connection: a disulfide bridge between the sulfur atoms of two cysteines within that chain. This closes a loop without making the entire molecule a head-to-tail ring. A sequence list and a connectivity diagram therefore describe different aspects of the same reference structure.

Fragment design versus a complete protein.

AOD-9604 uses a short region related to growth hormone with an N-terminal tyrosine. That relationship explains the design history, but the fragment does not contain the full protein’s sequence or architecture. Comparisons should identify the actual fragment and its bridge, rather than treating the parent protein’s name as a complete molecular description.

Structure and research references: [1]

03 / Read the evidence

Research & analytical context.

The reference record identifies a peptide fragment with an intramolecular disulfide bond. Sequence and disulfide connectivity describe different parts of its identity: residue order alone does not confirm that the intended bridge is present.

Read the references: [1][2].

The distinction that matters

Do not use full-length growth hormone data as a substitute for AOD-9604 evidence. Confirm the sequence, disulfide state and counterion against the supplied material’s documentation.

04 / From reference to record

Know the lot, too.

A publication describes its own test material. Your lot’s certificate describes what was tested on that lot. Keep the compound name, batch number and reported methods together when reviewing a result.

Identity & composition

Check sequence or chemical form, terminal modifications, counterion and—where relevant—each blend component.

Analytical results

Read purity, content, sterility and endotoxin results as separate measurements. Only call a test passed when the actual report supports it.

Handling & storage notes

Lyophilized material: Store at −20°C; protect from light and moisture.

Follow the material-specific label and supporting storage documentation. These temperatures do not establish a shelf life.

How to store lyophilized peptides

05 / Reference questions

A few details, explained.

Does a straight chain diagram mean AOD-9604 is linear?

No. A straight display can show residue order while omitting the cysteine bridge. For this reference, the disulfide connection must be described alongside the backbone; neither the compound name nor a straight sequence illustration shows every bond.

Is the acetate part of the peptide sequence?

No. Acetate in a reference record describes a counterion, separately from the peptide backbone. It should not be counted as an amino-acid residue. The chemical form listed for an external reference does not establish the form of a Pioneer lot.

Read alongside the references: [1]

06 / Continue reading

Go to the source.