01 / Naming
DAC or No DAC: what differs.
Both forms of CJC-1295 share one 29-residue chain, Modified GRF (1–29). It is the GHRH(1–29) reference sequence with the four substitutions below, and it ends in an amidated arginine.
The DAC form adds a 30th residue: a lysine at the C-terminus that carries a maleimidopropionyl group, the attachment supplier records call DAC. The No DAC form has neither, and it is the form in this blend.
| Position | GHRH(1–29) | Modified GRF (1–29) |
|---|---|---|
| 2 | Ala | D-Ala |
| 8 | Asn | Gln |
| 15 | Gly | Ala |
| 27 | Met | Leu |
02 / Molecular architecture
A closer look at the components.
The no-DAC reference is Modified GRF (1–29), a 29-residue peptide. Ipamorelin is a pentapeptide containing nonstandard and D-amino-acid residues. Mixing them does not produce a single 34-residue molecule.
- Modified GRF (1–29)
- Ipamorelin · 5 residues
- No DAC attachment
Reference information: [1][2][3][4][5]. Actual lot identity must be verified separately.
Two very different chain designs.
The no-DAC component is referenced as Modified GRF (1–29), while ipamorelin is a five-residue chain. Ipamorelin’s unusual residues and terminal amide illustrate why adding the residue counts is not a description of the formulation. Each molecule retains its own backbone, terminal groups and molecular mass.
Why the no-DAC qualifier matters.
The no-DAC wording distinguishes the reference from DAC-containing CJC-1295. It is an identity qualifier, not an optional display name. Comparisons should specify the actual GRF analog and attachment status before borrowing a structure or an experimental finding from another material carrying the CJC name.
03 / Composition
What each vial holds.
Each vial holds the two peptides in equal amounts by mass, in the 5/5mg size.
| Vial | CJC-1295 (No DAC) | Ipamorelin |
|---|---|---|
| 10mg | 5mg | 5mg |
04 / Read the evidence
Research & analytical context.
The reference structures distinguish a 29-residue modified GRF chain from a five-residue ipamorelin chain. Their sequences, terminal groups and molecular masses are separate specifications. A blend requires documentation of both, rather than a single combined sequence.
Read the references: [1][2][3][4][5].
The distinction that matters
No DAC is a meaningful identity distinction: do not borrow duration claims from DAC-containing CJC-1295. Equal milligrams of two peptides also do not mean equal numbers of molecules.
05 / From reference to record
Know the lot, too.
A publication describes its own test material. Your lot’s certificate describes what was tested on that lot. Keep the compound name, batch number and reported methods together when reviewing a result.
Identity & composition
Check sequence or chemical form, terminal modifications, counterion and—where relevant—each blend component.
Analytical results
Read purity, content, sterility and endotoxin results as separate measurements. Only call a test passed when the actual report supports it.
Handling & storage notes
Lyophilized material: Store at −20°C; protect from light and moisture.
Follow the material-specific label and supporting storage documentation. These temperatures do not establish a shelf life.
How to store lyophilized peptides06 / Reference questions
A few details, explained.
Does this pairing form one 34-residue chain?
No. A formulation containing a 29-residue peptide and a five-residue peptide remains a mixture of separate molecules. Creating one covalently joined chain would describe a different chemical entity.
Are equal milligrams equal proportions of molecules?
Not necessarily. The two chains have different molecular masses. A mass ratio and a molar ratio express different properties, so a component breakdown in milligrams should not be relabeled as a molecule-count ratio.
07 / Continue reading
Go to the source.
Each source is labeled by its type. External sources are not Pioneer batch certificates.
- Cayman Chemical · Modified GRF (1–29) reference identitySupplier reference · Read source (opens a new tab)
- Raun et al. · Ipamorelin discovery study (1998)Published research · Read source (opens a new tab)
- Cayman Chemical · CJC-1295 with DAC reference identitySupplier reference · Read source (opens a new tab)
- UniProt · GHRH precursor sequence record, P01286Public record · Read source (opens a new tab)
- PubChem · Ipamorelin identity record, CID 9831659Public record · Read source (opens a new tab)